导读：irrespective of [英] [ˌɪrisˈpektiv ɔv] [美] [ˌɪrɪˈspɛktɪv ʌv]不顾的，不考虑的，无论；在所不计；不计；

这属于一个长难句。主句是：The success of Sci-Hub shows ，宾语从句是：the legal ecosystem has lost legitimacy among its users. 非限制性定语从句是：which relies on researchers ... accessed, 定语从句中：关系代词which代替The success of Sci-Hub在定从中作主语，relies on 谓语，researchers 宾语，passing on copies 宾语补足语，they have themselves legally accessed 定语从句，修饰copies，关系代词that由于作accessed宾语，省去了。